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HomoloGene:7418. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MEN1,  H.sapiens
multiple endocrine neoplasia I
    NP_000235.2
615 aa
   MEN1,  P.troglodytes
multiple endocrine neoplasia I
    XP_001167101.2
615 aa
   LOC722041,  M.mulatta
menin-like
    XP_001118239.2
320 aa
   MEN1,  C.lupus
multiple endocrine neoplasia I
    NP_001074977.1
615 aa
   MEN1,  B.taurus
multiple endocrine neoplasia I
    NP_001069629.1
610 aa
   Men1,  M.musculus
multiple endocrine neoplasia 1
    NP_032609.1
611 aa
   Men1,  R.norvegicus
multiple endocrine neoplasia I
    NP_062081.1
610 aa
   men1,  X.tropicalis
multiple endocrine neoplasia I
    NP_001016361.1
674 aa
   men1,  D.rerio
multiple endocrine neoplasia I
    XP_003198971.1
617 aa
   Mnn1,  D.melanogaster
Menin 1
    NP_001036342.1
763 aa
   AgaP_AGAP008130,  A.gambiae
AgaP_AGAP008130
    XP_317329.4
706 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adrenal adenoma, somatic.
Angiofibroma, somatic.
Carcinoid tumor of lung.
Lipoma, somatic.
Multiple endocrine neoplasia I.
Parathyroid adenoma, somatic.
Prolactinoma, hyperparathyroidism, carcinoid syndrome.
Hyperparathyroidism, AD.



Publications
Articles associated with genes and sequences of this homology group.

The significance of MEN1 mutations in pituitary carcinomas.
Cuny T & Barlier A. Biomark Med 7, 567-9 (2013).
Menin: a scaffold protein that controls gene expression and cell signaling.
Matkar S, et al. Trends Biochem Sci 38, 394-402 (2013).
Multiple endocrine neoplasia type 1.
Agarwal SK. Front Horm Res 41, 1-15 (2013).
Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1).
Gaztambide S, et al. Minerva Endocrinol 38, 17-28 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Men1 includes H.sapiens MEN1 and R.norvegicus Men1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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