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HomoloGene:3355. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PARK2,  H.sapiens
parkin RBR E3 ubiquitin protein ligase
    NP_004553.2
465 aa
   PARK2,  P.troglodytes
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
    XP_001153913.1
465 aa
   LOC710899,  M.mulatta
e3 ubiquitin-protein ligase parkin-like
    XP_001099588.2
172 aa
   PARK2,  C.lupus
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
    XP_855152.2
464 aa
   PARK2,  B.taurus
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
    NP_001185994.1
488 aa
   Park2,  M.musculus
Parkinson disease (autosomal recessive, juvenile) 2, parkin
    NP_057903.1
464 aa
   Park2,  R.norvegicus
parkinson protein 2, E3 ubiquitin protein ligase
    NP_064478.1
465 aa
   PARK2,  G.gallus
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
    XP_004935613.1
463 aa
   park2,  D.rerio
Parkinson disease (autosomal recessive, juvenile) 2, parkin
    NP_001017635.1
458 aa
   park,  D.melanogaster
parkin
    NP_730601.1
482 aa
   AgaP_AGAP006580,  A.gambiae
AgaP_AGAP006580
    XP_316606.2
489 aa
   pdr-1,  C.elegans
pdr-1
    NP_499846.2
386 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adenocarcinoma of lung, somatic.
Parkinson disease, juvenile, type 2.
Adenocarcinoma, ovarian, somatic.
Leprosy, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Bit-by-bit autophagic removal of parkin-labelled mitochondria.
Yang JY & Yang WY. Nat Commun 4, 2428 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IBR (pfam01485)
  IBR domain.
UBQ (cl00155)
  Ubiquitin-like proteins.
IBR (cl19760)
  IBR domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Park2 includes H.sapiens PARK2 and R.norvegicus Park2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 8 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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