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HomoloGene:20412. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   C5,  H.sapiens
complement component 5
    NP_001726.2
1676 aa
   C5,  P.troglodytes
complement component 5
    XP_520228.2
1676 aa
   C5,  M.mulatta
complement component 5
    XP_001095750.2
1646 aa
   C5,  C.lupus
complement component 5
    XP_532046.3
1613 aa
   C5,  B.taurus
complement component 5
    NP_001160088.1
1677 aa
   Hc,  M.musculus
hemolytic complement
    NP_034536.1
1680 aa
   C5,  G.gallus
complement component 5
    XP_415405.4
1677 aa
   c5,  X.tropicalis
complement component 5
    NP_001190988.1
1688 aa
   c5,  D.rerio
complement component 5
    XP_001919226.4
1704 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
C5 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Genetic variants in C5 and poor response to eculizumab.
Nishimura J, et al. N Engl J Med 370, 632-9 (2014).
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.
Howell GR, et al. J Neuroinflammation 10, 76 (2013).
Protective effect of C5 shRNA on myocardial ischemia-reperfusion injury in rats.
Tang K, et al. Can J Physiol Pharmacol 90, 1394-402 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
A2M_recep (pfam07677)
  A-macroglobulin receptor.
A2M (pfam00207)
  Alpha-2-macroglobulin family.
A2M_N (pfam01835)
  MG2 domain.
A2M_N_2 (pfam07703)
  Alpha-2-macroglobulin family N-terminal region.
MG1 (pfam11974)
  Alpha-2-macroglobulin MG1 domain.
ANATO (cl00032)
  Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
NTR_like (cl02512)
  NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
A2M (pfam00207)
  Alpha-2-macroglobulin family.
A2M_recep (pfam07677)
  A-macroglobulin receptor.
MG1 (pfam11974)
  Alpha-2-macroglobulin MG1 domain.
NTR_like (cl02512)
  NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
ISOPREN_C2_like (cl08267)
  This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
A2M_N (cl19929)
  MG2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hc includes H.sapiens C5 and R.norvegicus C5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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