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HomoloGene:2459. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CLDN5,  H.sapiens
claudin 5
    NP_001124333.1
303 aa
   CLDN5,  P.troglodytes
claudin 5
    XP_530408.3
304 aa
   CLDN5,  C.lupus
claudin 5
    XP_005636646.1
284 aa
   CLDN5,  B.taurus
claudin 5
    NP_001069928.1
218 aa
   Cldn5,  M.musculus
claudin 5
    NP_038833.2
218 aa
   Cldn5,  R.norvegicus
claudin 5
    NP_113889.1
218 aa
   CLDN5,  G.gallus
claudin 5
    NP_989532.1
216 aa
   cldn5,  X.tropicalis
claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
    NP_001006707.1
216 aa
   cldn5b,  D.rerio
claudin 5b
    NP_001006044.2
220 aa
   cldn5a,  D.rerio
claudin 5a
    NP_998439.1
215 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Claudin-5 participates in the regulation of endothelial cell motility.
Escudero-Esparza A, et al. Mol Cell Biochem 362, 71-85 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PMP22_Claudin (cl15797)
  PMP-22/EMP/MP20/Claudin family.
PMP22_Claudin (cl17758)
  PMP-22/EMP/MP20/Claudin family.
Claudin_2 (cl17758)
  PMP-22/EMP/MP20/Claudin tight junction.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cldn5 includes H.sapiens CLDN5 and R.norvegicus Cldn5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (13 transcripts, 9 species)
Mammalia - mammals (10 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

 

 

 

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