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HomoloGene:40764. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LOC102724788,  H.sapiens
proline dehydrogenase 1, mitochondrial-like
    XP_006724998.1
600 aa
   PRODH,  H.sapiens
proline dehydrogenase (oxidase) 1
    NP_057419.4
600 aa
   PRODH,  P.troglodytes
proline dehydrogenase (oxidase) 1
    XP_525525.2
354 aa
   LOC695506,  M.mulatta
proline dehydrogenase, mitochondrial-like
    XP_001082216.1
310 aa
   PRODH,  C.lupus
proline dehydrogenase (oxidase) 1
    XP_005636623.1
568 aa
   PRODH,  B.taurus
proline dehydrogenase (oxidase) 1
    NP_001068653.1
593 aa
   Prodh,  M.musculus
proline dehydrogenase
    NP_035302.2
599 aa
   Prodh,  R.norvegicus
proline dehydrogenase (oxidase) 1
    NP_001129250.1
599 aa
   PRODH,  G.gallus
proline dehydrogenase (oxidase) 1
    XP_001234062.3
544 aa
   LOC100494891,  X.tropicalis
proline dehydrogenase 1, mitochondrial-like
    XP_002932121.2
622 aa
   LOC100537991,  D.rerio
proline dehydrogenase 1, mitochondrial-like
    XP_003198647.2
385 aa
   slgA,  D.melanogaster
sluggish A
    NP_996527.1
669 aa
   AgaP_AGAP003860,  A.gambiae
AgaP_AGAP003860
    XP_310420.5
710 aa
   CELE_B0513.5,  C.elegans
CELE_B0513.5
    NP_502669.2
616 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperprolinemia, type I.
Schizophrenia, susceptibility to, 4} 600850.



Publications
Articles associated with genes and sequences of this homology group.

Type I hyperprolinemia: genotype/phenotype correlations.
Guilmatre A, et al. Hum Mutat 31, 961-5 (2010).
Regulation and function of proline oxidase under nutrient stress.
Pandhare J, et al. J Cell Biochem 107, 759-68 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN02681 (PLN02681)
  proline dehydrogenase.
Pro_dh (pfam01619)
  Proline dehydrogenase.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Pro_dh (cl03282)
  Proline dehydrogenase.
Pro_dh (pfam01619)
  Proline dehydrogenase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prodh includes H.sapiens PRODH and R.norvegicus Prodh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

 

 

 

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