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HomoloGene:9155. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GEMIN5,  H.sapiens
gem (nuclear organelle) associated protein 5
    NP_056280.2
1508 aa
   GEMIN5,  P.troglodytes
gem (nuclear organelle) associated protein 5
    XP_527093.2
1508 aa
   GEMIN5,  M.mulatta
gem (nuclear organelle) associated protein 5
    XP_001112869.2
1513 aa
   GEMIN5,  C.lupus
gem (nuclear organelle) associated protein 5
    XP_005619319.1
1506 aa
   GEMIN5,  B.taurus
gem (nuclear organelle) associated protein 5
    XP_003586382.1
1509 aa
   Gemin5,  M.musculus
gem (nuclear organelle) associated protein 5
    NP_001160141.1
1503 aa
   Gemin5,  R.norvegicus
gem (nuclear organelle) associated protein 5
    NP_001165560.1
1497 aa
   GEMIN5,  G.gallus
gem (nuclear organelle) associated protein 5
    XP_414574.3
1504 aa
   gemin5,  X.tropicalis
gem (nuclear organelle) associated protein 5
    XP_004912844.1
1473 aa
   gemin5,  D.rerio
gem (nuclear organelle) associated protein 5
    XP_001339880.4
1440 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.
Bradrick SS & Gromeier M. PLoS One 4, e7030 (2009).
Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains.
Lau CK, et al. Nat Struct Mol Biol 16, 486-91 (2009).
Absence of gemin5 from SMN complexes in nuclear Cajal bodies.
Hao le T, et al. BMC Cell Biol 8, 28 (2007).
The SMN complex: an assembly machine for RNPs.
Battle DJ, et al. Cold Spring Harb Symp Quant Biol 71, 313-20 (2006).
The Gemin5 protein of the SMN complex identifies snRNAs.
Battle DJ, et al. Mol Cell 23, 273-9 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COG2319 (COG2319)
  FOG: WD40 repeat [General function prediction only].
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gemin5 includes H.sapiens GEMIN5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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