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HomoloGene:387. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RAG1,  H.sapiens
recombination activating gene 1
    NP_000439.1
1043 aa
   RAG1,  P.troglodytes
recombination activating gene 1
    XP_001154240.1
1043 aa
   RAG1,  M.mulatta
recombination activating gene 1
    XP_001084631.1
1043 aa
   RAG1,  C.lupus
recombination activating gene 1
    XP_540538.1
1043 aa
   RAG1,  B.taurus
recombination activating gene 1
    XP_005216456.1
1062 aa
   Rag1,  M.musculus
recombination activating gene 1
    NP_033045.2
1040 aa
   Rag1,  R.norvegicus
recombination activating gene 1
    NP_445920.1
1040 aa
   RAG1,  G.gallus
recombination activating gene 1
    NP_001026359.1
1041 aa
   rag1,  X.tropicalis
recombination activating gene 1
    XP_002937338.1
1046 aa
   rag1,  D.rerio
recombination activating gene 1
    NP_571464.1
1057 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Severe combined immunodeficiency, B cell-negative.
Omenn syndrome.
Alpha/beta T-cell lymphopenia with gamma/delta T-cell expansion, severe cytomegalovirus infection, and autoimmunity.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-RAG1 (pfam10426)
  Recombination-activating protein 1 zinc-finger domain.
RAG1 (pfam12940)
  Recombination-activation protein 1 (RAG1).
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rag1 includes H.sapiens RAG1 and R.norvegicus Rag1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 6 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

 

 

 

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