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HomoloGene:320. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   UROD,  H.sapiens
uroporphyrinogen decarboxylase
    NP_000365.3
367 aa
   UROD,  P.troglodytes
uroporphyrinogen decarboxylase
    XP_513127.1
367 aa
   UROD,  M.mulatta
uroporphyrinogen decarboxylase-like
    XP_002808261.1
367 aa
   UROD,  C.lupus
uroporphyrinogen decarboxylase
    XP_532602.3
367 aa
   UROD,  B.taurus
uroporphyrinogen decarboxylase
    NP_001192487.1
367 aa
   Urod,  M.musculus
uroporphyrinogen decarboxylase
    NP_033504.2
367 aa
   Urod,  R.norvegicus
uroporphyrinogen decarboxylase
    NP_062082.1
367 aa
   UROD,  G.gallus
uroporphyrinogen decarboxylase
    XP_004936797.1
375 aa
   urod,  X.tropicalis
uroporphyrinogen decarboxylase
    NP_001011486.2
372 aa
   urod,  D.rerio
uroporphyrinogen decarboxylase
    NP_571422.1
369 aa
   Updo,  D.melanogaster
Updo
    NP_001137627.1
379 aa
   AgaP_AGAP011895,  A.gambiae
AgaP_AGAP011895
    XP_320631.3
419 aa
   HEM12,  S.cerevisiae
HEM12
    NP_010332.3
362 aa
   KLLA0F11770g,  K.lactis
KLLA0F11770g
    XP_455614.1
369 aa
   AGOS_AGL210C,  E.gossypii
AGOS_AGL210C
    NP_986457.1
367 aa
   hem12,  S.pombe
hem12
    NP_588085.2
355 aa
   MGG_01622,  M.oryzae
MGG_01622
    XP_003714609.1
367 aa
   NCU02771,  N.crassa
NCU02771
    XP_964266.2
369 aa
   HEME2,  A.thaliana
HEME2
    NP_181581.1
394 aa
   Os03g0337600,  O.sativa
Os03g0337600
    NP_001050049.1
390 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Porphyria cutanea tarda.
Porphyria, hepatoerythropoietic.



Publications
Articles associated with genes and sequences of this homology group.

Hepatoerythropoietic Porphyria
Liu LU, et al. (1993).
Porphyria Cutanea Tarda, Type II
Liu LU, et al. (1993).
A tale of two acids: when arginine is a more appropriate acid than H3O+.
Silva PJ, et al. J Phys Chem B 114, 8994-9001 (2010).
Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.
Warby CA, et al. Cell Mol Biol (Noisy-le-grand) 55, 40-5 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
URO-D_CIMS_like (cl00464)
  The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Urod includes H.sapiens UROD and R.norvegicus Urod.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (10 transcripts, 10 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 12 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (8 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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