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HomoloGene:1997. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PLCG1,  H.sapiens
phospholipase C, gamma 1
    NP_002651.2
1291 aa
   PLCG1,  P.troglodytes
phospholipase C, gamma 1
    XP_514650.3
1291 aa
   PLCG1,  M.mulatta
phospholipase C, gamma 1
    XP_001087295.2
1326 aa
   PLCG1,  C.lupus
phospholipase C, gamma 1
    XP_005635117.1
1177 aa
   PLCG1,  B.taurus
phospholipase C, gamma 1
    NP_776850.1
1291 aa
   Plcg1,  M.musculus
phospholipase C, gamma 1
    NP_067255.2
1302 aa
   Plcg1,  R.norvegicus
phospholipase C, gamma 1
    NP_037319.1
1290 aa
   PLCG1,  G.gallus
phospholipase C, gamma 1
    XP_004947069.1
1280 aa
   plcg1,  D.rerio
phospholipase C, gamma 1
    NP_919388.1
1312 aa
   sl,  D.melanogaster
small wing
    NP_476726.2
1236 aa
   AgaP_AGAP011152,  A.gambiae
AgaP_AGAP011152
    XP_309496.4
1232 aa
   plc-3,  C.elegans
plc-3
    NP_496205.2
1350 aa
   PLC2,  A.thaliana
PLC2
    NP_187464.1
581 aa
   AT3G55940,  A.thaliana
AT3G55940
    NP_191153.1
584 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Phospholipase C-γ1 involved in brain disorders.
Jang HJ, et al. Adv Biol Regul 53, 51-62 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PI-PLC-Y (pfam00387)
  Phosphatidylinositol-specific phospholipase C, Y domain.
PI-PLCc_GDPD_SF (cl14615)
  Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.
EF-hand_like (cl08538)
  Phosphoinositide-specific phospholipase C, efhand-like.
C2 (cl14603)
  C2 domain.
PI-PLC-Y (cl14781)
  This associates with pfam00388 to form a single structural unit.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Plcg1 includes H.sapiens PLCG1 and R.norvegicus Plcg1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 4 species)
Mammalia - mammals (8 transcripts, 7 species)
Aves - birds (5 transcripts, 2 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Arthropoda
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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