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HomoloGene:4480. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LASP1,  H.sapiens
LIM and SH3 protein 1
    NP_006139.1
261 aa
   LASP1,  P.troglodytes
LIM and SH3 protein 1
    XP_511445.3
261 aa
   LASP1,  M.mulatta
LIM and SH3 protein 1
    XP_001085111.1
261 aa
   LASP1,  C.lupus
LIM and SH3 protein 1
    XP_864168.1
262 aa
   LASP1,  B.taurus
LIM and SH3 protein 1
    NP_001030471.1
260 aa
   Lasp1,  M.musculus
LIM and SH3 protein 1
    NP_034818.1
263 aa
   Lasp1,  R.norvegicus
LIM and SH3 protein 1
    NP_116002.1
263 aa
   LASP1,  G.gallus
LIM and SH3 protein 1
    NP_001170800.1
258 aa
   lasp1,  X.tropicalis
LIM and SH3 protein 1
    NP_001008445.1
258 aa
   lasp1,  D.rerio
LIM and SH3 protein 1
    NP_997801.1
234 aa
   AgaP_AGAP006526,  A.gambiae
AgaP_AGAP006526
    XP_001688892.1
651 aa
   F42H10.3,  C.elegans
F42H10.3
    NP_498874.2
335 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion.
Chew CS, et al. Am J Physiol Gastrointest Liver Physiol 295, G37-G44 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Nebulin (pfam00880)
  Nebulin repeat.
Nebulin (cl11595)
  Nebulin repeat.
LIM (cl02475)
  LIM is a small protein-protein interaction domain, containing two zinc fingers.
Nebulin (cl11595)
  Tandem arrays of these repeats are known to bind actin.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lasp1 includes H.sapiens LASP1 and R.norvegicus Lasp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (18 transcripts, 11 species)
Mammalia - mammals (14 transcripts, 11 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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