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HomoloGene:7960. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   STAT3,  H.sapiens
signal transducer and activator of transcription 3 (acute-phase response factor)
    NP_644805.1
770 aa
   STAT3,  P.troglodytes
signal transducer and activator of transcription 3 (acute-phase response factor)
    XP_001165417.2
863 aa
   STAT3,  M.mulatta
signal transducer and activator of transcription 3 (acute-phase response factor)
    XP_002800523.1
864 aa
   STAT3,  C.lupus
signal transducer and activator of transcription 3 (acute-phase response factor)
    XP_005624514.1
770 aa
   STAT3,  B.taurus
signal transducer and activator of transcription 3 (acute-phase response factor)
    NP_001012689.2
770 aa
   Stat3,  M.musculus
signal transducer and activator of transcription 3
    NP_998824.1
770 aa
   Stat3,  R.norvegicus
signal transducer and activator of transcription 3 (acute-phase response factor)
    NP_036879.1
770 aa
   STAT3,  G.gallus
signal transducer and activator of transcription 3 (acute-phase response factor)
    NP_001026102.1
771 aa
   LOC100498278,  X.tropicalis
signal transducer and activator of transcription 3.1-like
    XP_002941970.2
692 aa
   stat3,  D.rerio
signal transduction and activation of transcription 3
    NP_571554.1
806 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperimmunoglobulin E recurrent infection syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Mechanisms of STAT3 activation in the liver of FXR knockout mice.
Li G, et al. Am J Physiol Gastrointest Liver Physiol 305, G829-37 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
STAT_bind (pfam02864)
  STAT protein, DNA binding domain.
STAT_alpha (pfam01017)
  STAT protein, all-alpha domain.
STAT_int (cl03749)
  STAT protein, protein interaction domain.
STAT_alpha (pfam01017)
  STAT protein, all-alpha domain.
STAT_int (cl03749)
  STAT protein, protein interaction domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Stat3 includes H.sapiens STAT3 and R.norvegicus Stat3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (14 transcripts, 9 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

 

 

 

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