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HomoloGene:56427. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PLXNA2,  H.sapiens
plexin A2
    NP_079455.3
1894 aa
   PLXNA2,  P.troglodytes
plexin A2
    XP_003308771.1
1909 aa
   PLXNA2,  M.mulatta
plexin A2
    XP_001110951.2
1909 aa
   PLXNA2,  C.lupus
plexin A2
    XP_547389.2
1909 aa
   PLXNA2,  B.taurus
plexin A2
    NP_001193586.1
1894 aa
   Plxna2,  M.musculus
plexin A2
    NP_032908.2
1894 aa
   Plxna2,  R.norvegicus
plexin A2
    NP_001099458.2
1894 aa
   PLXNA2,  G.gallus
plexin A2
    XP_004935035.1
1899 aa
   plxna2,  X.tropicalis
plexin A2
    NP_001116947.1
1898 aa
   si:dkey-164k14.1,  D.rerio
si:dkey-164k14.1
    XP_689780.5
1902 aa
   plexA,  D.melanogaster
plexin A
    NP_524637.2
1945 aa
   AgaP_AGAP000064,  A.gambiae
AgaP_AGAP000064
    XP_311092.3
1919 aa
   plx-1,  C.elegans
plx-1
    NP_500018.3
1945 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population.
Fujii T, et al. Prog Neuropsychopharmacol Biol Psychiatry 31, 873-7 (2007).
Anxiety and comorbid measures associated with PLXNA2.
Wray NR, et al. Arch Gen Psychiatry 64, 318-26 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Plexin_cytopl (pfam08337)
  Plexin cytoplasmic RasGAP domain.
PSI (pfam01437)
  Plexin repeat.
TIG (pfam01833)
  IPT/TIG domain.
RasGAP (cl02569)
  Ras GTPase Activating Domain.
IPT (cl15674)
  Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
Sema (cl15693)
  The Sema domain, a protein interacting module, of semaphorins and plexins.
RasGAP (cl02569)
  Ras GTPase Activating Domain.
PSI (cl02601)
  A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Sema (cl15693)
  The Sema domain, a protein interacting module, of semaphorins and plexins.
IPT (cl15674)
  Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Plxna2 includes H.sapiens PLXNA2 and R.norvegicus Plxna2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 7 species)
Mammalia - mammals (9 transcripts, 8 species)
Ascidiacea - tunicates (7 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (3 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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