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HomoloGene:618. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DDC,  H.sapiens
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    NP_000781.1
480 aa
   DDC,  P.troglodytes
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    XP_519096.2
480 aa
   DDC,  M.mulatta
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    XP_001082132.1
480 aa
   DDC,  C.lupus
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    XP_848285.2
506 aa
   DDC,  B.taurus
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    NP_776332.1
487 aa
   Ddc,  M.musculus
dopa decarboxylase
    NP_001177377.1
480 aa
   Ddc,  R.norvegicus
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    NP_036677.1
480 aa
   DDC,  G.gallus
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    XP_419032.3
485 aa
   ddc,  X.tropicalis
dopa decarboxylase (aromatic L-amino acid decarboxylase)
    NP_001011289.1
485 aa
   ddc,  D.rerio
dopa decarboxylase
    NP_998507.1
480 aa
   Ddc,  D.melanogaster
Dopa decarboxylase
    NP_724163.1
510 aa
   AgaP_AGAP009091,  A.gambiae
AgaP_AGAP009091
    XP_319841.3
519 aa
   NCU08275,  N.crassa
NCU08275
    XP_961903.1
508 aa
   AT2G20340,  A.thaliana
AT2G20340
    NP_849999.1
490 aa
   Os07g0437500,  O.sativa
Os07g0437500
    NP_001059509.1
497 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Structural gene for dopa decarboxylase (DDC, 3-4-dihydroxy-L-phenylalanine-carboxylase) which catalyzes the decarboxylation of dopa to dopamine (Lunan and Mitchell, 1969) and 5-hydroxytryptophan to serotonin (5-hydroxytryptamine) but not tyrosine to tyramine (Livingstone and Tempel, 1983). Native DDC isolated from mature larvae is a homodimer with subunit molecular weight 54kD (Clark et al., 1978). Distinct DDC isoforms are generated in the CNS and hypoderm by alternate splicing of the Ddc primary transcript; the CNS isoform differs by the addition of 35 amino acids at the amino terminus (Morgan, Johnson and Hirsh, 1986). (See FlyBase for complete description.)

H.sapiens
Aromatic L-amino acid decarboxylase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

The DOPA decarboxylase (DDC) gene is associated with alerting attention.
Zhu B, et al. Prog Neuropsychopharmacol Biol Psychiatry 43, 140-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AAT_I (cl18945)
  Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ddc includes H.sapiens DDC and R.norvegicus Ddc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Arthropoda
Insecta - insects (30 transcripts, 13 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (6 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (4 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (48 transcripts, 28 species)
Liliopsida - monocots (4 transcripts, 4 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (2 transcripts, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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