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HomoloGene:502. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IL6,  H.sapiens
interleukin 6 (interferon, beta 2)
    NP_000591.1
212 aa
   IL6,  P.troglodytes
interleukin 6 (interferon, beta 2)
    XP_518992.2
212 aa
   IL6,  M.mulatta
interleukin 6 (interferon, beta 2)
    NP_001036198.1
212 aa
   IL6,  C.lupus
interleukin 6 (interferon, beta 2)
    NP_001003301.1
207 aa
   Il6,  M.musculus
interleukin 6
    NP_112445.1
211 aa
   Il6,  R.norvegicus
interleukin 6
    NP_036721.1
211 aa
   IL6,  G.gallus
interleukin 6 (interferon, beta 2)
    NP_989959.1
241 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Kaposi sarcoma, susceptibility to.
Osteopenia/osteoporosis.



Publications
Articles associated with genes and sequences of this homology group.

Interleukin-6 signaling drives fibrosis in unresolved inflammation.
Fielding CA, et al. Immunity 40, 40-50 (2014).
[Expressions and correlations of let-7a and IL-6 in esophageal squamous cell carcinoma].
Chen D, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29, 1181-4 (2013).
Chicken IL-6 is a heat-shock gene.
Prakasam R, et al. FEBS Lett 587, 3541-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IL6 (cl02473)
  Interleukin-6/G-CSF/MGF family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Il6 includes H.sapiens IL6 and R.norvegicus Il6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Aves - birds (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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