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HomoloGene:6814. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DLAT,  H.sapiens
dihydrolipoamide S-acetyltransferase
    NP_001922.2
647 aa
   DLAT,  P.troglodytes
dihydrolipoamide S-acetyltransferase
    XP_003313345.1
647 aa
   DLAT,  M.mulatta
dihydrolipoamide S-acetyltransferase
    XP_001107013.1
647 aa
   DLAT,  C.lupus
dihydrolipoamide S-acetyltransferase
    XP_546524.2
647 aa
   DLAT,  B.taurus
dihydrolipoamide S-acetyltransferase
    NP_001192659.2
647 aa
   Dlat,  M.musculus
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
    NP_663589.3
642 aa
   Dlat,  R.norvegicus
dihydrolipoamide S-acetyltransferase
    NP_112287.1
632 aa
   DLAT,  G.gallus
dihydrolipoamide S-acetyltransferase
    XP_417933.3
632 aa
   dlat,  X.tropicalis
dihydrolipoamide S-acetyltransferase
    NP_001016320.2
628 aa
   dlat,  D.rerio
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
    NP_997832.1
652 aa
   CG5261,  D.melanogaster
CG5261
    NP_001260196.1
512 aa
   AgaP_AGAP007975,  A.gambiae
AgaP_AGAP007975
    XP_317493.4
512 aa
   dlat-1,  C.elegans
dlat-1
    NP_506579.1
507 aa
   LAT1,  S.cerevisiae
LAT1
    NP_014328.3
482 aa
   KLLA0F04741g,  K.lactis
KLLA0F04741g
    XP_455294.1
473 aa
   AGOS_AER364W,  E.gossypii
AGOS_AER364W
    NP_985220.1
453 aa
   lat1,  S.pombe
lat1
    NP_587755.1
483 aa
   MGG_09878,  M.oryzae
MGG_09878
    XP_003720354.1
464 aa
   NCU07659,  N.crassa
NCU07659
    XP_962786.1
458 aa
   AT3G13930,  A.thaliana
AT3G13930
    NP_566470.1
539 aa
   AT1G54220,  A.thaliana
AT1G54220
    NP_001031186.1
539 aa
   Os06g0105400,  O.sativa
Os06g0105400
    NP_001056555.1
550 aa
   Os02g0105200,  O.sativa
Os02g0105200
    NP_001045618.1
548 aa
   Os07g0410100,  O.sativa
Os07g0410100
    NP_001059445.1
541 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pyruvate dehydrogenase E2 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Changes in brain gene expression after long-term sleep deprivation.
Cirelli C, et al. J Neurochem 98, 1632-45 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ATP_sub_h (pfam10775)
  ATP synthase complex subunit h.
E3_binding (pfam02817)
  e3 binding domain.
2-oxoacid_dh (pfam00198)
  2-oxoacid dehydrogenases acyltransferase (catalytic domain).
2-oxoacid_dh (pfam00198)
  2-oxoacid dehydrogenases acyltransferase (catalytic domain).
E3_binding (pfam02817)
  e3 binding domain.
Biotinyl_lipoyl_domains (cl11404)
  Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dlat includes H.sapiens DLAT and R.norvegicus Dlat.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (54 transcripts, 34 species)
Liliopsida - monocots (19 transcripts, 9 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Mammalia - mammals (19 transcripts, 13 species)
Actinopterygii - bony fishes (13 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (19 transcripts, 12 species)
Arachnida - arachnids (3 transcripts, 2 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (11 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (3 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (3 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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