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HomoloGene:48591. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MAP2K2,  H.sapiens
mitogen-activated protein kinase kinase 2
    NP_109587.1
400 aa
   LOC100611792,  P.troglodytes
dual specificity mitogen-activated protein kinase kinase 2-like
    XP_003318859.1
529 aa
   MAP2K2,  M.mulatta
mitogen-activated protein kinase kinase 2
    XP_001118016.2
383 aa
   MAP2K2,  C.lupus
mitogen-activated protein kinase kinase 2
    NP_001041601.1
400 aa
   MAP2K2,  B.taurus
mitogen-activated protein kinase kinase 2
    NP_001033160.2
400 aa
   Map2k2,  M.musculus
mitogen-activated protein kinase kinase 2
    NP_075627.2
401 aa
   Map2k2,  R.norvegicus
mitogen activated protein kinase kinase 2
    NP_579817.1
400 aa
   MAP2K2,  G.gallus
mitogen-activated protein kinase kinase 2
    NP_990719.1
398 aa
   map2k2a,  D.rerio
mitogen-activated protein kinase kinase 2a
    NP_001032468.2
397 aa
   map2k2b,  D.rerio
mitogen-activated protein kinase kinase 2b
    NP_001121753.1
395 aa
   STE7,  S.cerevisiae
STE7
    NP_010122.1
515 aa
   KLLA0C16577g,  K.lactis
KLLA0C16577g
    XP_452941.1
504 aa
   AGOS_ACR196C,  E.gossypii
AGOS_ACR196C
    NP_983598.1
530 aa
   MKK6,  A.thaliana
MKK6
    NP_200469.1
356 aa
   Os01g0510100,  O.sativa
Os01g0510100
    NP_001043164.1
355 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cardiofaciocutaneous syndrome.



Publications
Articles associated with genes and sequences of this homology group.

A full-length 3D structure for MAPK/ERK kinase 2 (MEK2).
Liang H, et al. Sci China Life Sci 54, 336-41 (2011).
Cardiofaciocutaneous syndrome in a mother and two sons with a MEK2 mutation.
Linden HC & Price SM. Clin Dysmorphol 20, 86-8 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Map2k2 includes H.sapiens MAP2K2 and R.norvegicus Map2k2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (21 transcripts, 16 species)
Liliopsida - monocots (10 transcripts, 9 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Actinopterygii - bony fishes (21 transcripts, 10 species)
Mammalia - mammals (16 transcripts, 11 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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