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HomoloGene:115. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FH,  H.sapiens
fumarate hydratase
    NP_000134.2
510 aa
   FH,  P.troglodytes
fumarate hydratase
    XP_001159979.1
510 aa
   FH,  M.mulatta
fumarate hydratase
    XP_001094968.1
510 aa
   FH,  C.lupus
fumarate hydratase
    XP_537215.1
508 aa
   FH,  B.taurus
fumarate hydratase
    NP_001069271.1
510 aa
   Fh1,  M.musculus
fumarate hydratase 1
    NP_034339.2
507 aa
   Fh,  R.norvegicus
fumarate hydratase
    NP_058701.2
507 aa
   FH,  G.gallus
fumarate hydratase
    NP_001006382.1
507 aa
   LOC100491219,  X.tropicalis
fumarate hydratase, mitochondrial-like
    XP_002935862.2
497 aa
   fh,  D.rerio
fumarate hydratase
    NP_957257.1
509 aa
   l(1)G0255,  D.melanogaster
lethal (1) G0255
    NP_572339.1
495 aa
   AgaP_AGAP001884,  A.gambiae
AgaP_AGAP001884
    XP_321179.4
503 aa
   fum-1,  C.elegans
fum-1
    NP_498642.1
501 aa
   FUM1,  S.cerevisiae
FUM1
    NP_015061.1
488 aa
   KLLA0D00902g,  K.lactis
KLLA0D00902g
    XP_453112.1
492 aa
   AGOS_ACR013C,  E.gossypii
AGOS_ACR013C
    NP_983416.2
488 aa
   fum1,  S.pombe
fum1
    NP_588397.3
520 aa
   MGG_17962,  M.oryzae
MGG_17962
    XP_003720956.1
546 aa
   NCU10008,  N.crassa
NCU10008
    XP_959454.1
533 aa
   FUM1,  A.thaliana
FUM1
    NP_001078075.1
492 aa
   FUM2,  A.thaliana
FUM2
    NP_199908.1
499 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Multiple cutaneous and uterine leiomyomata.
Leiomyomatosis and renal cell cancer.
Fumarase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Fumarase deficiency in dichorionic diamniotic twins.
Tregoning S, et al. Twin Res Hum Genet 16, 1117-20 (2013).
Fumarate hydratase gene mutation in two young patients with sporadic uterine fibroids.
Kubinova K, et al. J Obstet Gynaecol Res 39, 410-4 (2013).
Structural basis of fumarate hydratase deficiency.
Picaud S, et al. J Inherit Metab Dis 34, 671-6 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN00134 (PLN00134)
  fumarate hydratase; Provisional.
fumC (PRK00485)
  fumarate hydratase; Reviewed.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fh1 includes H.sapiens FH and R.norvegicus Fh1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 15 species)
Actinopterygii - bony fishes (12 transcripts, 10 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (22 transcripts, 12 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (44 transcripts, 29 species)
Liliopsida - monocots (12 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (12 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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