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HomoloGene:104. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   F5,  H.sapiens
coagulation factor V (proaccelerin, labile factor)
2224 aa
   F5,  P.troglodytes
coagulation factor V (proaccelerin, labile factor)
2591 aa
   F5,  M.mulatta
coagulation factor V (proaccelerin, labile factor)
2191 aa
   F5,  C.lupus
coagulation factor V (proaccelerin, labile factor)
2222 aa
   F5,  B.taurus
coagulation factor V (proaccelerin, labile factor)
2211 aa
   F5,  M.musculus
coagulation factor V
2183 aa
   F5,  R.norvegicus
coagulation factor V (proaccelerin, labile factor)
2102 aa
   F5,  G.gallus
coagulation factor V (proaccelerin, labile factor)
1922 aa
   f5,  X.tropicalis
coagulation factor V (proaccelerin, labile factor)
2011 aa
   f5,  D.rerio
coagulation factor V
2101 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hemorrhagic diathesis due to factor V deficiency.
Thromboembolism susceptibility due to factor V Leiden.
Thrombophilia due to factor V Liverpool.
Budd-Chiari syndrome.

Articles associated with genes and sequences of this homology group.

Parahemophilia: new insights into factor v deficiency.
Thalji N & Camire RM. Semin Thromb Hemost 39, 607-12 (2013).
Factor V Leiden mutation-related chronic skin ulcers.
Kayatas K, et al. Int J Low Extrem Wounds 12, 35-8 (2013).
Livedoid vasculopathy and its association with factor V Leiden mutation.
Yong AA, et al. Singapore Med J 53, e258-60 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COX2 (cl11412)
  Cytochrome C oxidase subunit II, periplasmic domain.
Cu-oxidase (pfam00394)
  Multicopper oxidase.
Cu-oxidase_2 (pfam07731)
  Multicopper oxidase.
Cu-oxidase_3 (pfam07732)
  Multicopper oxidase.
COG5048 (COG5048)
  FOG: Zn-finger [General function prediction only].
ARG80 (COG5068)
  Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription].
PRK06933 (PRK06933)
  type III secretion system protein; Validated.
Lamp (pfam01299)
  Lysosome-associated membrane glycoprotein (Lamp).
FA58C (cl19067)
  Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Cupredoxin (cl19115)
  Cupredoxin superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus F5 includes H.sapiens F5 and R.norvegicus F5.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)




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