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HomoloGene:41676. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KAT8,  H.sapiens
K(lysine) acetyltransferase 8
    NP_115564.2
458 aa
   KAT8,  P.troglodytes
K(lysine) acetyltransferase 8
    XP_523493.4
456 aa
   KAT8,  C.lupus
K(lysine) acetyltransferase 8
    XP_536904.2
458 aa
   KAT8,  B.taurus
K(lysine) acetyltransferase 8
    NP_001098953.1
458 aa
   Kat8,  M.musculus
K(lysine) acetyltransferase 8
    NP_080646.1
458 aa
   Kat8,  R.norvegicus
K (lysine) acetyltransferase 8
    NP_001017378.1
458 aa
   kat8,  X.tropicalis
K(lysine) acetyltransferase 8
    NP_001016234.2
465 aa
   kat8,  D.rerio
K(lysine) acetyltransferase 8
    NP_997907.1
487 aa
   mof,  D.melanogaster
males absent on the first
    NP_511051.1
827 aa
   AgaP_AGAP012229,  A.gambiae
AgaP_AGAP012229
    XP_320309.4
445 aa
   mys-2,  C.elegans
mys-2
    NP_493467.1
550 aa
   HAM1,  A.thaliana
HAM1
    NP_201266.1
445 aa
   HAM2,  A.thaliana
HAM2
    NP_196536.1
445 aa
   Os07g0626600,  O.sativa
Os07g0626600
    NP_001060338.1
450 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Autoacetylation of the MYST lysine acetyltransferase MOF protein.
Yang C, et al. J Biol Chem 287, 34917-26 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tudor-knot (pfam11717)
  RNA binding activity-knot of a chromodomain.
MOZ_SAS (pfam01853)
  MOZ/SAS family.
NAT_SF (cl17182)
  N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate.
CHROMO (cl17459)
  Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence implicates the chromo domain in the binding activity of these proteins to methylated histone tails and maybe RNA. May occur as single instance, in a tandem arrangement or followd by a related "chromo shadow" domain.
MOZ_SAS (cl19766)
  MOZ/SAS family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kat8 includes H.sapiens KAT8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (17 transcripts, 10 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Arachnida - arachnids (2 transcripts, 2 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (41 transcripts, 32 species)
Liliopsida - monocots (7 transcripts, 6 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (3 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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