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HomoloGene:30951. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   APOE,  H.sapiens
apolipoprotein E
    NP_000032.1
317 aa
   APOE,  P.troglodytes
apolipoprotein E
    NP_001009007.1
317 aa
   APOE,  M.mulatta
apolipoprotein E
    XP_001104482.2
263 aa
   APOE,  C.lupus
apolipoprotein E
    XP_866043.1
323 aa
   APOE,  B.taurus
apolipoprotein E
    NP_776416.1
316 aa
   Apoe,  M.musculus
apolipoprotein E
    NP_033826.2
311 aa
   Apoe,  R.norvegicus
apolipoprotein E
    NP_620183.2
312 aa
   apoe,  X.tropicalis
apolipoprotein E
    XP_004912063.1
275 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alzheimer disease-2.
Hyperlipoproteinemia, type III.
Myocardial infarction susceptibility.
Sea-blue histiocyte disease.
Macular degeneration, age-related.



Publications
Articles associated with genes and sequences of this homology group.

CD8(+)CD25(+) T cells reduce atherosclerosis in apoE(-/-) mice.
Zhou J, et al. Biochem Biophys Res Commun 443, 864-70 (2014).
Neuroprotective Sirtuin ratio reversed by ApoE4.
Theendakara V, et al. Proc Natl Acad Sci U S A 110, 18303-8 (2013).
Hyperglycemia impairs atherosclerosis regression in mice.
Gaudreault N, et al. Am J Pathol 183, 1981-92 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Apolipoprotein (pfam01442)
  Apolipoprotein A1/A4/E domain.
Apolipoprotein (pfam01442)
  Apolipoprotein A1/A4/E domain.
GrpE (cl03075)
  GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Apoe includes H.sapiens APOE and R.norvegicus Apoe.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 7 species)

 

 

 

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