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HomoloGene:41317. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TLR4,  H.sapiens
toll-like receptor 4
839 aa
   TLR4,  P.troglodytes
toll-like receptor 4
839 aa
   TLR4,  M.mulatta
toll-like receptor 4
826 aa
   TLR4,  C.lupus
toll-like receptor 4
833 aa
   TLR4,  B.taurus
toll-like receptor 4
841 aa
   Tlr4,  M.musculus
toll-like receptor 4
835 aa
   Tlr4,  R.norvegicus
toll-like receptor 4
835 aa
   TLR4,  G.gallus
toll-like receptor 4
843 aa
   tlr4al,  D.rerio
toll-like receptor 4a, like
816 aa
   tlr4ba,  D.rerio
toll-like receptor 4b, duplicate a
750 aa
   tlr4bb,  D.rerio
toll-like receptor 4b, duplicate b
817 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Endotoxin hyporesponsiveness.

Articles associated with genes and sequences of this homology group.

Polymorphisms of the TLR4 gene and risk of gastric cancer.
Huang L, et al. Gene 537, 46-50 (2014).
Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition.
Xue J & Habtezion A. J Clin Invest 124, 437-47 (2014).
Endogenous IgG affects the cell biology of RPE cells and involves the TLR4 pathway.
Niu N, et al. Invest Ophthalmol Vis Sci 54, 7045-52 (2013).
Extracellular hemin crisis triggers acute chest syndrome in sickle mice.
Ghosh S, et al. J Clin Invest 123, 4809-20 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_8 (pfam13855)
  Leucine rich repeat.
LRRCT (smart00082)
  Leucine rich repeat C-terminal domain.
TIR (pfam01582)
  TIR domain.
COG4886 (COG4886)
  Leucine-rich repeat (LRR) protein [Function unknown].
LRR_8 (pfam13855)
  Leucine rich repeat.
TIR_2 (cl17458)
  TIR domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tlr4 includes H.sapiens TLR4 and R.norvegicus Tlr4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)




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