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HomoloGene:2412. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   NFE2L2,  H.sapiens
nuclear factor, erythroid 2-like 2
605 aa
   NFE2L2,  P.troglodytes
nuclear factor (erythroid-derived 2)-like 2
605 aa
   NFE2L2,  C.lupus
nuclear factor, erythroid 2-like 2
601 aa
   NFE2L2,  B.taurus
nuclear factor (erythroid-derived 2)-like 2
607 aa
   Nfe2l2,  M.musculus
nuclear factor, erythroid derived 2, like 2
597 aa
   Nfe2l2,  R.norvegicus
nuclear factor, erythroid 2-like 2
597 aa
   NFE2L2,  G.gallus
nuclear factor (erythroid-derived 2)-like 2
582 aa
   nfe2l2,  X.tropicalis
nuclear factor, erythroid 2-like 2
589 aa
   nfe2l2a,  D.rerio
nuclear factor (erythroid-derived 2)-like 2a
586 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.
Ludtmann MH, et al. Biochem J 457, 415-24 (2014).
Neuronal activity regulates astrocytic Nrf2 signaling.
Habas A, et al. Proc Natl Acad Sci U S A 110, 18291-6 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
B_zip1 (cl02576)
  basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nfe2l2 includes H.sapiens NFE2L2 and R.norvegicus Nfe2l2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (19 transcripts, 14 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)




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