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HomoloGene:41614. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SPG11,  H.sapiens
spastic paraplegia 11 (autosomal recessive)
    NP_079413.3
2443 aa
   LOC712221,  M.mulatta
spatacsin-like
    XP_002808495.1
2367 aa
   SPG11,  C.lupus
spastic paraplegia 11 (autosomal recessive)
    XP_003640073.2
2441 aa
   SPG11,  B.taurus
spastic paraplegia 11 (autosomal recessive)
    XP_002691138.2
2428 aa
   Spg11,  M.musculus
spastic paraplegia 11
    NP_663506.2
2430 aa
   Spg11,  R.norvegicus
spastic paraplegia 11 (autosomal recessive)
    NP_001178500.1
2315 aa
   SPG11,  G.gallus
spastic paraplegia 11 (autosomal recessive)
    XP_003641879.2
2425 aa
   spg11,  D.rerio
spastic paraplegia 11
    NP_001181923.1
2379 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Spastic paraplegia-11.



Publications
Articles associated with genes and sequences of this homology group.

White and grey matter abnormalities in patients with SPG11 mutations.
França MC Jr, et al. J Neurol Neurosurg Psychiatry 83, 828-33 (2012).
Alu elements mediate large SPG11 gene rearrangements: further spatacsin mutations.
Conceição Pereira M, et al. Genet Med 14, 143-51 (2012).
Exome sequencing reveals SPG11 mutations causing juvenile ALS.
Daoud H, et al. Neurobiol Aging 33, 839.e5-9 (2012).
Spastic Paraplegia 11
Stevanin G, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
cas_Cpf1 (TIGR04330)
  CRISPR-associated protein Cpf1, subtype PREFRAN.
Spatacsin_C (pfam14649)
  Spatacsin C-terminus.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Spg11 includes H.sapiens SPG11.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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