Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:68063. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CYP21A2,  H.sapiens
cytochrome P450, family 21, subfamily A, polypeptide 2
    NP_000491.4
495 aa
   LOC745345,  P.troglodytes
steroid 21-hydroxylase-like
    XP_003311237.1
495 aa
   CYP21A2,  M.mulatta
cytochrome P450, family 21, subfamily A, polypeptide 2
    XP_001114240.1
495 aa
   CYP21A2,  C.lupus
cytochrome P450c21
    NP_001003335.1
492 aa
   CYP21,  B.taurus
cytochrome P450, subfamily XXI (steroid 21-hydroxylase)
    NP_001013614.1
496 aa
   Cyp21a1,  M.musculus
cytochrome P450, family 21, subfamily a, polypeptide 1
    NP_034125.2
487 aa
   Cyp21a1,  R.norvegicus
cytochrome P450, family 21, subfamily a, polypeptide 1
    NP_476442.2
493 aa
   CYP21A2,  G.gallus
cytochrome P450, family 21, subfamily A, polypeptide 2
    NP_001092828.1
478 aa
   LOC100489813,  X.tropicalis
steroid 21-hydroxylase-like
    XP_002941314.2
510 aa
   LOC793249,  D.rerio
steroid 21-hydroxylase-like
    XP_005157984.1
522 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency.
Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

CYP21A2 mutations in women with polycystic ovary syndrome (PCOS).
Settas N, et al. Horm Metab Res 45, 383-6 (2013).
Adult height of subjects with nonclassical 21-hydroxylase deficiency.
Eyal O, et al. Acta Paediatr 102, 419-23 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
p450 (pfam00067)
  Cytochrome P450.
p450 (cl12078)
  Cytochrome P450.
p450 (cl12078)
  Cytochrome P450.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cyp21a1 includes H.sapiens CYP21A1P and R.norvegicus Cyp21a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Aves - birds (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

Write to the Help Desk