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HomoloGene:7507. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RAG2,  H.sapiens
recombination activating gene 2
    NP_001230714.1
527 aa
   RAG2,  P.troglodytes
recombination activating gene 2
    XP_521889.1
527 aa
   RAG2,  M.mulatta
recombination activating gene 2
    XP_001114734.2
532 aa
   RAG2,  C.lupus
recombination activating gene 2
    XP_005631162.1
527 aa
   RAG2,  B.taurus
recombination activating gene 2
    NP_001075938.1
527 aa
   Rag2,  M.musculus
recombination activating gene 2
    NP_033046.1
527 aa
   Rag2,  R.norvegicus
recombination activating gene 2
    NP_001093998.1
527 aa
   RAG2,  G.gallus
recombination activating gene 2
    XP_004941607.1
570 aa
   rag2,  X.tropicalis
V(D)J recombination-activating protein 2
    XP_002937337.2
520 aa
   rag2,  D.rerio
recombination activating gene 2
    NP_571460.2
530 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Severe combined immunodeficiency, B cell-negative.
Omenn syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Characterization of HIV-1 infection in the humanized Rag2-/-γc-/- mouse model.
Sanchez FM & Berges BK. Methods Mol Biol 1031, 215-22 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RAG2_PHD (pfam13341)
  RAG2 PHD domain.
RAG2 (pfam03089)
  Recombination activating protein 2.
Kelch_3 (pfam13415)
  Galactose oxidase, central domain.
RAG2 (pfam03089)
  Recombination activating protein 2.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rag2 includes H.sapiens RAG2 and R.norvegicus Rag2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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