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HomoloGene:2237. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SCN9A,  H.sapiens
sodium channel, voltage-gated, type IX, alpha subunit
    NP_002968.1
1977 aa
   SCN9A,  P.troglodytes
sodium channel, voltage-gated, type IX, alpha subunit
    XP_003309333.2
2010 aa
   SCN9A,  M.mulatta
sodium channel, voltage-gated, type IX, alpha subunit
    XP_001101662.2
1977 aa
   SCN9A,  C.lupus
sodium channel, voltage-gated, type IX, alpha subunit
    XP_005640317.1
1992 aa
   SCN9A,  B.taurus
sodium channel, voltage-gated, type IX, alpha subunit
    NP_001104257.1
1987 aa
   Scn9a,  M.musculus
sodium channel, voltage-gated, type IX, alpha
    NP_061340.2
1975 aa
   Scn9a,  R.norvegicus
sodium channel, voltage-gated, type IX, alpha
    NP_579823.1
1984 aa
   SCN9A,  G.gallus
sodium channel, voltage-gated, type IX, alpha subunit
    XP_004942840.1
1991 aa
   scn2a,  X.tropicalis
sodium channel, voltage-gated, type II, alpha subunit
    XP_002939316.2
1957 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Erythermalgia, primary.
Paroxysmal extreme pain disorder.
Insensitivity to pain, channelopathy-associated.



Publications
Articles associated with genes and sequences of this homology group.

[Association between mutations of SCN9A gene and pain related to Parkinsonism].
Zhang LM, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 17-20 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IQ (cl15479)
  IQ calmodulin-binding motif.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
IQ (cl15479)
  Calmodulin-binding motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn9a includes H.sapiens SCN9A and R.norvegicus Scn9a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)

 

 

 

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