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HomoloGene:20437. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COL4A1,  H.sapiens
collagen, type IV, alpha 1
    NP_001836.2
1669 aa
   COL4A1,  P.troglodytes
collagen, type IV, alpha 1
    XP_003314261.2
1770 aa
   COL4A1,  M.mulatta
collagen, type IV, alpha 1
    XP_001088660.2
1607 aa
   COL4A1,  C.lupus
collagen, type IV, alpha 1
    XP_005634201.1
1645 aa
   COL4A1,  B.taurus
collagen, type IV, alpha 1
    NP_001159983.1
1669 aa
   Col4a1,  M.musculus
collagen, type IV, alpha 1
    NP_034061.2
1669 aa
   Col4a1,  R.norvegicus
collagen, type IV, alpha 1
    NP_001128481.1
1669 aa
   COL4A1,  G.gallus
collagen, type IV, alpha 1
    NP_001155871.1
1669 aa
   col4a1,  X.tropicalis
collagen alpha-1(IV) chain
    XP_002933064.2
1669 aa
   col4a1,  D.rerio
collagen, type IV, alpha 1
    XP_694040.5
1640 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Porencephaly.
Brain small vessel disease with hemorrhage.



Publications
Articles associated with genes and sequences of this homology group.

Hereditary cerebral small vessel diseases: a review.
Federico A, et al. J Neurol Sci 322, 25-30 (2012).
Childhood presentation of COL4A1 mutations.
Shah S, et al. Dev Med Child Neurol 54, 569-74 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
C4 (cl02467)
  C-terminal tandem repeated domain in type 4 procollagen.
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Col4a1 includes H.sapiens COL4A1 and R.norvegicus Col4a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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