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HomoloGene:30952. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ATM,  H.sapiens
ataxia telangiectasia mutated
    NP_000042.3
3056 aa
   ATM,  P.troglodytes
ataxia telangiectasia mutated
    XP_001139405.2
3019 aa
   ATM,  M.mulatta
ataxia telangiectasia mutated
    XP_002799825.1
2968 aa
   ATM,  C.lupus
ataxia telangiectasia mutated
    NP_001124300.1
3056 aa
   ATM,  B.taurus
ataxia telangiectasia mutated
    NP_001192864.1
3054 aa
   Atm,  M.musculus
ataxia telangiectasia mutated homolog (human)
    NP_031525.2
3066 aa
   Atm,  R.norvegicus
ataxia telangiectasia mutated
    NP_001100291.1
3064 aa
   ATM,  G.gallus
ataxia telangiectasia mutated
    NP_001155872.1
3050 aa
   atm,  X.tropicalis
ataxia telangiectasia mutated
    XP_002934974.2
3060 aa
   atm,  D.rerio
ataxia telangiectasia mutated
    XP_002664603.2
2451 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer, susceptibility to.
Ataxia-telangiectasia.
Lymphoma, B-cell non-Hodgkin, somatic.
Lymphoma, mantle cell.
T-cell prolymphocytic leukemia, sporadic.



Publications
Articles associated with genes and sequences of this homology group.

Ataxia telangiectasia presenting as dopa-responsive cervical dystonia.
Charlesworth G, et al. Neurology 81, 1148-51 (2013).
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
Shiloh Y & Ziv Y. Nat Rev Mol Cell Biol 14, 197-210 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FATC (pfam02260)
  FATC domain.
FAT (pfam02259)
  FAT domain.
TAN (pfam11640)
  Telomere-length maintenance and DNA damage repair.
FAT (pfam02259)
  FAT domain.
FATC (pfam02260)
  FATC domain.
TAN (pfam11640)
  Telomere-length maintenance and DNA damage repair.
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Atm includes H.sapiens ATM and R.norvegicus Atm.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 11 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 2 species)
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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