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HomoloGene:21008. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NTN1,  H.sapiens
netrin 1
    NP_004813.2
604 aa
   NTN1,  P.troglodytes
netrin 1
    XP_511846.3
725 aa
   NTN1,  M.mulatta
netrin 1
    XP_001113322.2
608 aa
   NTN1,  C.lupus
netrin 1
    XP_850304.2
604 aa
   NTN1,  B.taurus
netrin 1
    NP_001179495.1
603 aa
   Ntn1,  M.musculus
netrin 1
    NP_032770.2
604 aa
   Ntn1,  R.norvegicus
netrin 1
    NP_446183.2
604 aa
   NTN1,  G.gallus
netrin 1
    NP_990750.1
606 aa
   ntn1a,  D.rerio
netrin 1a
    NP_571104.1
603 aa
   NetB,  D.melanogaster
Netrin-B
    NP_511155.1
793 aa
   AgaP_AGAP000228,  A.gambiae
AgaP_AGAP000228
    XP_310904.5
666 aa
   unc-6,  C.elegans
unc-6
    NP_509165.1
612 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Protective role for netrin-1 during diabetic nephropathy.
Tak E, et al. J Mol Med (Berl) 91, 1071-80 (2013).
Netrin-1 attracts axons through FAK-dependent mechanotransduction.
Moore SW, et al. J Neurosci 32, 11574-85 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Laminin_EGF (pfam00053)
  Laminin EGF-like (Domains III and V).
NTR_like (cl02512)
  NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
EGF_Lam (cl19065)
  Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ntn1 includes H.sapiens NTN1 and R.norvegicus Ntn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 6 species)
Mammalia - mammals (10 transcripts, 7 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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