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HomoloGene:32030. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GATA2,  H.sapiens
GATA binding protein 2
    NP_116027.2
480 aa
   GATA2,  P.troglodytes
GATA binding protein 2
    XP_516728.2
480 aa
   GATA2,  C.lupus
GATA binding protein 2
    XP_541740.3
480 aa
   GATA2,  B.taurus
GATA binding protein 2
    NP_001179043.1
480 aa
   Gata2,  M.musculus
GATA binding protein 2
    NP_032116.4
480 aa
   Gata2,  R.norvegicus
GATA binding protein 2
    NP_254277.1
480 aa
   GATA2,  G.gallus
GATA binding protein 2
    NP_001003797.1
466 aa
   LOC100487142,  X.tropicalis
GATA-binding factor 2-like
    XP_002933110.2
451 aa
   gata2a,  D.rerio
GATA-binding protein 2a
    NP_571308.1
456 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The evolution of cellular deficiency in GATA2 mutation.
Dickinson RE, et al. Blood 123, 863-74 (2014).
Gata2 is required for HSC generation and survival.
de Pater E, et al. J Exp Med 210, 2843-50 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ZnF_GATA (cl00158)
  Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gata2 includes H.sapiens GATA2 and R.norvegicus Gata2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 7 species)
Mammalia - mammals (10 transcripts, 10 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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