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HomoloGene:68389. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RUNX2,  H.sapiens
runt-related transcription factor 2
    NP_001019801.3
521 aa
   RUNX2,  P.troglodytes
runt-related transcription factor 2
    XP_001142127.2
591 aa
   RUNX2,  M.mulatta
runt-related transcription factor 2
    XP_001100855.1
590 aa
   RUNX2,  B.taurus
runt-related transcription factor 2
    XP_002697308.2
586 aa
   Runx2,  M.musculus
runt related transcription factor 2
    NP_001139510.1
528 aa
   Runx2,  R.norvegicus
runt-related transcription factor 2
    NP_001265412.1
529 aa
   RUNX2,  G.gallus
runt-related transcription factor 2
    NP_989459.1
472 aa
   runx2,  X.tropicalis
runt-related transcription factor 2
    NP_001128588.1
468 aa
   runx2a,  D.rerio
runt-related transcription factor 2a
    NP_998023.1
467 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cleidocranial dysplasia.
Dental anomalies, isolated.



Publications
Articles associated with genes and sequences of this homology group.

Biology of RUNX2 and Cleidocranial Dysplasia.
Cohen MM Jr. J Craniofac Surg 24, 130-3 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Runt (pfam00853)
  Runt domain.
RunxI (pfam08504)
  Runx inhibition domain.
Runt (pfam00853)
  Runt domain.
RunxI (pfam08504)
  Runx inhibition domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Runx2 includes H.sapiens RUNX2 and R.norvegicus Runx2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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