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HomoloGene:293. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SNCA,  H.sapiens
synuclein, alpha (non A4 component of amyloid precursor)
    NP_001139527.1
140 aa
   SNCA,  P.troglodytes
synuclein, alpha (non A4 component of amyloid precursor)
    NP_001009158.1
140 aa
   SNCA,  C.lupus
synuclein, alpha (non A4 component of amyloid precursor)
    XP_860942.1
140 aa
   SNCA,  B.taurus
synuclein, alpha (non A4 component of amyloid precursor)
    NP_001029213.1
140 aa
   Snca,  M.musculus
synuclein, alpha
    NP_001035916.1
140 aa
   Snca,  R.norvegicus
synuclein, alpha (non A4 component of amyloid precursor)
    NP_062042.1
140 aa
   SNCA,  G.gallus
synuclein, alpha (non A4 component of amyloid precursor)
    NP_990004.1
143 aa
   snca,  X.tropicalis
synuclein, alpha (non A4 component of amyloid precursor)
    NP_001090876.1
140 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dementia, Lewy body.
Parkinson disease, familial.
Parkinson disease 4, autosomal dominant Lewy body.



Publications
Articles associated with genes and sequences of this homology group.

α-Synuclein is localized to mitochondria-associated ER membranes.
Guardia-Laguarta C, et al. J Neurosci 34, 249-59 (2014).
Transmission of multiple system atrophy prions to transgenic mice.
Watts JC, et al. Proc Natl Acad Sci U S A 110, 19555-60 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Snca includes H.sapiens SNCA and R.norvegicus Snca.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

 

 

 

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