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HomoloGene:2338. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   SOX4,  H.sapiens
SRY (sex determining region Y)-box 4
474 aa
   SOX4,  P.troglodytes
SRY (sex determining region Y)-box 4
474 aa
   SOX4,  M.mulatta
SRY (sex determining region Y)-box 4
475 aa
   SOX4,  C.lupus
SRY (sex determining region Y)-box 4
357 aa
   SOX4,  B.taurus
SRY (sex determining region Y)-box 4
481 aa
   Sox4,  M.musculus
SRY (sex determining region Y)-box 4
440 aa
   Sox4,  R.norvegicus
SRY (sex determining region Y)-box 4
440 aa
   sox4,  X.tropicalis
SRY (sex determining region Y)-box 4
387 aa
   sox4b,  D.rerio
SRY-box containing gene 4b
342 aa
   sox4a,  D.rerio
SRY-box containing gene 4a
363 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Epigenetic regulation of Sox4 during palate development.
Seelan RS, et al. Epigenomics 5, 131-46 (2013).
Sox4 is required for the survival of pro-B cells.
Sun B, et al. J Immunol 190, 2080-9 (2013).
SOX4 expression levels in urothelial bladder carcinoma.
Gunes S, et al. Pathol Res Pract 207, 423-7 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sox4 includes H.sapiens SOX4 and R.norvegicus Sox4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 7 species)
Actinopterygii - bony fishes (9 transcripts, 5 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Echinoidea - sea urchins (2 transcripts, 1 species)

Anthozoa - anthozoans (1 transcript, 1 species)




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