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HomoloGene:1898. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NTRK1,  H.sapiens
neurotrophic tyrosine kinase, receptor, type 1
NP_002520.2
796 aa
NTRK1,  P.troglodytes
neurotrophic tyrosine kinase, receptor, type 1
XP_003308563.1
822 aa
NTRK1,  M.mulatta
neurotrophic tyrosine kinase, receptor, type 1
XP_001114243.2
822 aa
NTRK1,  C.lupus
neurotrophic tyrosine kinase, receptor, type 1
XP_851619.3
796 aa
NTRK1,  B.taurus
neurotrophic tyrosine kinase, receptor, type 1
XP_002686012.2
795 aa
Ntrk1,  M.musculus
neurotrophic tyrosine kinase, receptor, type 1
NP_001028296.1
799 aa
Ntrk1,  R.norvegicus
neurotrophic tyrosine kinase, receptor, type 1
NP_067600.1
799 aa
NTRK1,  G.gallus
neurotrophic tyrosine kinase, receptor, type 1
NP_990709.1
790 aa
ntrk1,  X.tropicalis
neurotrophic tyrosine kinase, receptor, type 1
XP_002939035.1
808 aa
ntrk1,  D.rerio
neurotrophic tyrosine kinase, receptor, type 1
XP_697246.5
797 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Medullary thyroid carcinoma, familial.
Insensitivity to pain, congenital, with anhidrosis.



Publications
Articles associated with genes and sequences of this homology group.

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.
Vaishnavi A, et al. Nat Med 19, 1469-72 (2013).
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells.
Pajtler KW, et al. Int J Cancer 133, 908-19 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_8 (pfam13855)
  Leucine rich repeat.
LRRCT (smart00082)
  Leucine rich repeat C-terminal domain.
IG (smart00409)
  Immunoglobulin.
IG_like (smart00410)
  Immunoglobulin like.
Ig (cl11960)
  Immunoglobulin domain.
I-set (pfam07679)
  Immunoglobulin I-set domain.
LRR_8 (pfam13855)
  Leucine rich repeat.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ntrk1 includes H.sapiens NTRK1 and R.norvegicus Ntrk1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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