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HomoloGene:7247. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BMP4,  H.sapiens
bone morphogenetic protein 4
    NP_001193.2
408 aa
   BMP4,  P.troglodytes
bone morphogenetic protein 4
    XP_509954.3
408 aa
   BMP4,  M.mulatta
bone morphogenetic protein 4
    XP_002805115.1
408 aa
   BMP4,  C.lupus
bone morphogenetic protein 4
    XP_864167.2
409 aa
   BMP4,  B.taurus
bone morphogenetic protein 4
    NP_001039342.1
409 aa
   Bmp4,  M.musculus
bone morphogenetic protein 4
    NP_031580.2
408 aa
   Bmp4,  R.norvegicus
bone morphogenetic protein 4
    NP_036959.2
408 aa
   BMP4,  G.gallus
bone morphogenetic protein 4
    NP_990568.3
404 aa
   bmp4,  X.tropicalis
bone morphogenetic protein 4
    NP_001017034.2
400 aa
   bmp4,  D.rerio
bone morphogenetic protein 4
    NP_571417.1
400 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Microphthalmia, syndromic 6.



Publications
Articles associated with genes and sequences of this homology group.

Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.
Zhang Y, et al. Arterioscler Thromb Vasc Biol 34, 152-9 (2014).
The role of focal adhesion kinase in BMP4 induction of mesenchymal stem cell adipogenesis.
Lee JS, et al. Biochem Biophys Res Commun 435, 696-701 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TGFb_propeptide (pfam00688)
  TGF-beta propeptide.
TGFb_propeptide (pfam00688)
  TGF-beta propeptide.
TGF_beta (cl02510)
  Transforming growth factor beta like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bmp4 includes H.sapiens BMP4 and R.norvegicus Bmp4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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