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HomoloGene:21005. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NRXN1,  H.sapiens
neurexin 1
    NP_001129131.1
1547 aa
   NRXN1,  P.troglodytes
neurexin 1
    XP_003309056.1
1547 aa
   NRXN1,  M.mulatta
neurexin 1
    XP_002799265.1
1547 aa
   NRXN1,  C.lupus
neurexin 1
    XP_005626154.1
1514 aa
   NRXN1,  B.taurus
neurexin 1
    NP_776829.1
1530 aa
   Nrxn1,  M.musculus
neurexin I
    NP_064648.3
1507 aa
   Nrxn1,  R.norvegicus
neurexin 1
    NP_068535.2
1507 aa
   NRXN1,  G.gallus
neurexin 1
    NP_001185904.1
1503 aa
   nrxn1,  X.tropicalis
neurexin 1
    XP_002935428.2
1486 aa
   nrxn1a,  D.rerio
neurexin 1a
    NP_001073490.1
1491 aa
   nrx-1,  C.elegans
nrx-1
    NP_001122868.2
1716 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
?Autism, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Genome-wide association study of lung cancer in Korean non-smoking women.
Kim JH, et al. J Korean Med Sci 28, 840-7 (2013).
Exon-disrupting deletions of NRXN1 in idiopathic generalized epilepsy.
Møller RS, et al. Epilepsia 54, 256-64 (2013).
Mutations affecting synaptic levels of neurexin-1β in autism and mental retardation.
Camacho-Garcia RJ, et al. Neurobiol Dis 47, 135-43 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
4.1m (smart00294)
  putative band 4.1 homologues' binding motif.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nrxn1 includes H.sapiens NRXN1 and R.norvegicus Nrxn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 12 species)
Actinopterygii - bony fishes (15 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

 

 

 

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