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HomoloGene:540. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TGFB1,  H.sapiens
transforming growth factor, beta 1
    NP_000651.3
390 aa
   TGFB1,  P.troglodytes
transforming growth factor, beta 1
    XP_512687.2
390 aa
   TGFB1,  C.lupus
transforming growth factor, beta 1
    NP_001003309.1
390 aa
   TGFB1,  B.taurus
transforming growth factor, beta 1
    NP_001159540.1
390 aa
   Tgfb1,  M.musculus
transforming growth factor, beta 1
    NP_035707.1
390 aa
   Tgfb1,  R.norvegicus
transforming growth factor, beta 1
    NP_067589.1
390 aa
   tgfb1,  X.tropicalis
transforming growth factor, beta 1
    XP_002939433.1
381 aa
   LOC563884,  D.rerio
transforming growth factor beta-1-like
    XP_692338.3
379 aa
   tgfb1a,  D.rerio
transforming growth factor, beta 1a
    NP_878293.1
377 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Camurati-Engelmann disease.
Cystic fibrosis lung disease, modifier of.



Publications
Articles associated with genes and sequences of this homology group.

TGF-β: duality of function between tumor prevention and carcinogenesis.
Principe DR, et al. J Natl Cancer Inst 106, djt369 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TGF_beta (pfam00019)
  Transforming growth factor beta like domain.
TGFb_propeptide (pfam00688)
  TGF-beta propeptide.
TGFb_propeptide (pfam00688)
  TGF-beta propeptide.
TGF_beta (cl02510)
  Transforming growth factor beta like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tgfb1 includes H.sapiens TGFB1 and R.norvegicus Tgfb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)

 

 

 

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