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HomoloGene:38289. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHEK2,  H.sapiens
checkpoint kinase 2
    NP_001005735.1
586 aa
   CHEK2,  P.troglodytes
checkpoint kinase 2
    XP_003317205.1
586 aa
   CHEK2,  M.mulatta
checkpoint kinase 2
    XP_001101658.1
589 aa
   CHEK2,  C.lupus
checkpoint kinase 2
    XP_005636447.1
590 aa
   CHEK2,  B.taurus
CHK2 checkpoint homolog (S. pombe)
    NP_001029703.1
534 aa
   Chek2,  M.musculus
checkpoint kinase 2
    NP_057890.1
546 aa
   Chek2,  R.norvegicus
checkpoint kinase 2
    NP_446129.1
545 aa
   CHEK2,  G.gallus
checkpoint kinase 2
    NP_001073576.1
522 aa
   chek2,  X.tropicalis
checkpoint kinase 2
    NP_001119996.1
511 aa
   chek2,  D.rerio
CHK2 checkpoint homolog (S. pombe)
    NP_956339.1
503 aa
   lok,  D.melanogaster
loki
    NP_724241.1
459 aa
   AgaP_AGAP009784,  A.gambiae
AgaP_AGAP009784
    XP_318879.3
462 aa
   CELE_T08D2.7,  C.elegans
CELE_T08D2.7
    NP_508060.1
469 aa
   chk-2,  C.elegans
chk-2
    NP_001024271.1
476 aa
   RAD53,  S.cerevisiae
RAD53
    NP_015172.1
821 aa
   KLLA0F11143g,  K.lactis
KLLA0F11143g
    XP_455587.1
813 aa
   AGOS_ACR142W,  E.gossypii
AGOS_ACR142W
    NP_983544.2
847 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer, susceptibility to.
Prostate cancer, familial.
Osteosarcoma, somatic.
Breast and colorectal cancer, susceptibility to.
Li-Fraumeni syndrome.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
Pkinase (pfam00069)
  Protein kinase domain.
FHA (cl00062)
  Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chek2 includes H.sapiens CHEK2 and R.norvegicus Chek2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 2 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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