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HomoloGene:3657. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   MECP2,  H.sapiens
methyl CpG binding protein 2 (Rett syndrome)
486 aa
   MECP2,  P.troglodytes
methyl CpG binding protein 2 (Rett syndrome)
498 aa
   MECP2,  M.mulatta
methyl CpG binding protein 2 (Rett syndrome)
486 aa
   MECP2,  C.lupus
methyl CpG binding protein 2 (Rett syndrome)
486 aa
   MECP2,  B.taurus
methyl CpG binding protein 2 (Rett syndrome)
486 aa
   Mecp2,  M.musculus
methyl CpG binding protein 2
484 aa
   Mecp2,  R.norvegicus
methyl CpG binding protein 2
492 aa
   mecp2,  X.tropicalis
methyl CpG binding protein 2 (Rett syndrome)
466 aa
   mecp2,  D.rerio
methyl CpG binding protein 2
524 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Angelman syndrome.
PPM-X syndrome.
Mental retardation, X-linked, with progressive spasticity.
Mental retardation, X-linked.
Autism, susceptibility to, X-linked-3.
Rett syndrome.
Rett syndrome, preserved speech variant.

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MBD (cl00110)
  MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mecp2 includes H.sapiens MECP2 and R.norvegicus Mecp2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 10 species)
Amphibia - amphibians (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)




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