Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:460. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TP53,  H.sapiens
tumor protein p53
    NP_000537.3
393 aa
   TP53,  P.troglodytes
tumor protein p53
    XP_001172077.2
393 aa
   TP53,  M.mulatta
tumor protein p53
    NP_001040616.1
393 aa
   TP53,  C.lupus
tumor protein p53
    NP_001003210.1
381 aa
   TP53,  B.taurus
tumor protein p53
    NP_776626.1
386 aa
   Trp53,  M.musculus
transformation related protein 53
    NP_035770.2
390 aa
   Tp53,  R.norvegicus
tumor protein p53
    NP_112251.2
391 aa
   tp53,  X.tropicalis
tumor protein p53
    NP_001001903.1
362 aa
   tp53,  D.rerio
tumor protein p53
    NP_001258749.1
374 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer.
Colorectal cancer.
Hepatocellular carcinoma.
Li-Fraumeni syndrome.
Nasopharyngeal carcinoma.
Histiocytoma.
Multiple malignancy syndrome.
Osteosarcoma.
Thyroid carcinoma.
Adrenal cortical carcinoma.
Pancreatic cancer.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P53_tetramer (pfam07710)
  P53 tetramerisation motif.
P53_TAD (pfam08563)
  P53 transactivation motif.
P53 (cl14608)
  P53 DNA-binding domain.
P53_tetramer (pfam07710)
  P53 tetramerization motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trp53 includes H.sapiens TP53 and R.norvegicus Tp53.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 15 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

Write to the Help Desk