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HomoloGene:3963. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   WNT1,  H.sapiens
wingless-type MMTV integration site family, member 1
    NP_005421.1
370 aa
   WNT1,  P.troglodytes
wingless-type MMTV integration site family, member 1
    XP_001159566.1
370 aa
   WNT1,  M.mulatta
wingless-type MMTV integration site family, member 1
    XP_001105191.1
370 aa
   WNT1,  C.lupus
wingless-type MMTV integration site family, member 1
    XP_543686.3
370 aa
   WNT1,  B.taurus
wingless-type MMTV integration site family, member 1
    NP_001107663.1
370 aa
   Wnt1,  M.musculus
wingless-related MMTV integration site 1
    NP_067254.1
370 aa
   Wnt1,  R.norvegicus
wingless-type MMTV integration site family, member 1
    NP_001099184.1
370 aa
   LOC100491444,  X.tropicalis
protein Wnt-1-like
    XP_002935152.1
372 aa
   wnt1,  D.rerio
wingless-type MMTV integration site family, member 1
    NP_001188327.1
370 aa
   wg,  D.melanogaster
wingless
    NP_523502.1
468 aa
   AgaP_AGAP009734,  A.gambiae
AgaP_AGAP009734
    XP_553580.3
456 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Patterning and growth control by membrane-tethered Wingless.
Alexandre C, et al. Nature 505, 180-5 (2014).
WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.
Laine CM, et al. N Engl J Med 368, 1809-16 (2013).
Mutations in WNT1 are a cause of osteogenesis imperfecta.
Fahiminiya S, et al. J Med Genet 50, 345-8 (2013).
Wnt1 is anti-lymphangiogenic in a melanoma mouse model.
Niederleithner H, et al. J Invest Dermatol 132, 2235-44 (2012).
Wnt signaling in amygdala-dependent learning and memory.
Maguschak KA & Ressler KJ. J Neurosci 31, 13057-67 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
wnt (pfam00110)
  wnt family.
wnt (cl19568)
  wnt family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Wnt1 includes H.sapiens WNT1 and R.norvegicus Wnt1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 5 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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