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HomoloGene:3038. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FKBP5,  H.sapiens
FK506 binding protein 5
NP_004108.1
457 aa
FKBP5,  P.troglodytes
FK506 binding protein 5
XP_001172420.1
457 aa
FKBP5,  C.lupus
FK506 binding protein 5
XP_538880.2
456 aa
FKBP5,  B.taurus
FK506 binding protein 5
NP_001179791.1
457 aa
Fkbp5,  M.musculus
FK506 binding protein 5
NP_034350.1
456 aa
Fkbp5,  R.norvegicus
FK506 binding protein 5
NP_001012174.1
456 aa
FKBP5,  G.gallus
FK506 binding protein 5
NP_001005431.1
449 aa
fkbp5,  D.rerio
FK506 binding protein 5
NP_998314.1
453 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Major depressive disorder and accelerated response to antidepressant drug treatment.



Publications
Articles associated with genes and sequences of this homology group.

Induction of FKBP51 by aldosterone in intestinal epithelium.
Petrovich E, et al. J Steroid Biochem Mol Biol 139, 78-87 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FKBP_C (pfam00254)
  FKBP-type peptidyl-prolyl cis-trans isomerase.
TPR_11 (pfam13414)
  TPR repeat.
TPR (cd00189)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR_11 (pfam13414)
  TPR repeat.
FKBP_C (cl19519)
  FKBP-type peptidyl-prolyl cis-trans isomerase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fkbp5 includes H.sapiens FKBP5 and R.norvegicus Fkbp5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (90 transcripts, 34 species)
Liliopsida - monocots (31 transcripts, 9 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Isoetopsida - club-mosses (3 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 1 species)

Chordata
Actinopterygii - bony fishes (13 transcripts, 8 species)
Mammalia - mammals (12 transcripts, 10 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Malacostraca - crustaceans (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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