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HomoloGene:907. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   ARHGAP5,  H.sapiens
Rho GTPase activating protein 5
1502 aa
   ARHGAP5,  P.troglodytes
Rho GTPase activating protein 5
1502 aa
   ARHGAP5,  M.mulatta
Rho GTPase activating protein 5
1502 aa
   ARHGAP5,  C.lupus
Rho GTPase activating protein 5
1503 aa
   ARHGAP5,  B.taurus
Rho GTPase activating protein 5
1413 aa
   Arhgap5,  M.musculus
Rho GTPase activating protein 5
1503 aa
   Arhgap5,  R.norvegicus
Rho GTPase activating protein 5
1245 aa
   ARHGAP5,  G.gallus
Rho GTPase activating protein 5
1505 aa
   arhgap5,  X.tropicalis
Rho GTPase activating protein 5
1500 aa
   arhgap5,  D.rerio
Rho GTPase activating protein 5
1502 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
Heckman-Stoddard BM, et al. Breast Cancer Res 11, R61 (2009).
p190RhoGAP is cell cycle regulated and affects cytokinesis.
Su L, et al. J Cell Biol 163, 571-82 (2003).
p190-B RhoGAP regulates mammary ductal morphogenesis.
Chakravarty G, et al. Mol Endocrinol 17, 1054-65 (2003).
p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.
Foster R, et al. Mol Cell Biol 14, 7173-81 (1994).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
FF (cl02610)
  This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arhgap5 includes H.sapiens ARHGAP5 and R.norvegicus Arhgap5.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (21 transcripts, 13 species)
Actinopterygii - bony fishes (13 transcripts, 6 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Chromadorea - nematodes (2 transcripts, 2 species)

Gastropoda - gastropods (1 transcript, 1 species)

Anthozoa - anthozoans (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)




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