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HomoloGene:32049. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NOTCH1,  H.sapiens
notch 1
    NP_060087.3
2555 aa
   NOTCH1,  P.troglodytes
notch 1
    XP_520371.2
2555 aa
   LOC709947,  M.mulatta
neurogenic locus notch homolog protein 1-like
    XP_002808138.1
2463 aa
   NOTCH1,  C.lupus
notch 1
    XP_005625490.1
2621 aa
   NOTCH1,  B.taurus
notch 1
    XP_002691666.2
2534 aa
   Notch1,  M.musculus
notch 1
    NP_032740.3
2531 aa
   Notch1,  R.norvegicus
notch 1
    NP_001099191.1
2531 aa
   NOTCH1,  G.gallus
notch 1
    XP_415420.4
2561 aa
   notch1,  X.tropicalis
notch 1
    NP_001090757.1
2522 aa
   notch1b,  D.rerio
notch homolog 1b
    NP_571377.2
2465 aa
   N,  D.melanogaster
Notch
    NP_001245510.1
2703 aa
   AgaP_AGAP001015,  A.gambiae
AgaP_AGAP001015
    XP_309208.5
2800 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Aortic valve disease.
Leukemia, T-cell acute lymphoblastic.



Publications
Articles associated with genes and sequences of this homology group.

Loss of Notch1 disrupts the barrier repair in the corneal epithelium.
Movahedan A, et al. PLoS One 8, e69113 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NOD (pfam06816)
  NOTCH protein.
NODP (pfam07684)
  NOTCH protein.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Notch (pfam00066)
  LNR domain.
DUF3454 (pfam11936)
  Domain of unknown function (DUF3454).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
NODP (pfam07684)
  NOTCH protein.
DUF3454 (pfam11936)
  Domain of unknown function (DUF3454).
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
Notch (cl02419)
  LNR domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Notch1 includes H.sapiens NOTCH1 and R.norvegicus Notch1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (10 transcripts, 4 species)
Mammalia - mammals (8 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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