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HomoloGene:7219. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SHOC2,  H.sapiens
soc-2 suppressor of clear homolog (C. elegans)
    NP_031399.2
582 aa
   SHOC2,  P.troglodytes
soc-2 suppressor of clear homolog (C. elegans)
    XP_521602.2
582 aa
   SHOC2,  M.mulatta
soc-2 suppressor of clear homolog (C. elegans)
    XP_001087610.1
582 aa
   SHOC2,  C.lupus
soc-2 suppressor of clear homolog (C. elegans)
    XP_535013.2
582 aa
   SHOC2,  B.taurus
soc-2 suppressor of clear homolog (C. elegans)
    NP_001095413.1
582 aa
   Shoc2,  M.musculus
soc-2 (suppressor of clear) homolog (C. elegans)
    NP_062632.2
582 aa
   Shoc2,  R.norvegicus
soc-2 suppressor of clear homolog (C. elegans)
    NP_001013173.1
582 aa
   SHOC2,  G.gallus
soc-2 suppressor of clear homolog (C. elegans)
    NP_001026407.1
529 aa
   shoc2,  X.tropicalis
soc-2 suppressor of clear homolog (C. elegans)
    XP_004915781.1
582 aa
   shoc2,  D.rerio
soc-2 suppressor of clear homolog (C. elegans)
    NP_001038251.1
561 aa
   Sur-8,  D.melanogaster
Sur-8
    NP_001262665.1
694 aa
   AgaP_AGAP004485,  A.gambiae
AgaP_AGAP004485
    XP_313783.5
595 aa
   soc-2,  C.elegans
soc-2
    NP_741391.2
558 aa
   Os10g0119200,  O.sativa
Os10g0119200
    NP_001064062.2
1092 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Noonan-like syndrome with loose anagen hair.



Publications
Articles associated with genes and sequences of this homology group.

The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.
Matsunaga-Udagawa R, et al. J Biol Chem 285, 7818-26 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
LRRNT_2 (pfam08263)
  Leucine rich repeat N-terminal domain.
LRR_8 (pfam13855)
  Leucine rich repeat.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Shoc2 includes H.sapiens SHOC2 and R.norvegicus Shoc2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (5 transcripts, 4 species)
Liliopsida - monocots (4 transcripts, 4 species)

 

 

 

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