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HomoloGene:8509. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NRG1,  H.sapiens
neuregulin 1
    NP_001153467.1
607 aa
   NRG1,  P.troglodytes
neuregulin 1
    XP_001168989.1
645 aa
   NRG1,  C.lupus
neuregulin 1
    XP_857861.1
643 aa
   NRG1,  B.taurus
neuregulin 1
    XP_005226139.1
618 aa
   Nrg1,  R.norvegicus
neuregulin 1
    NP_001258059.1
651 aa
   LOC100496613,  X.tropicalis
pro-neuregulin-1, membrane-bound isoform-like
    XP_002934037.2
639 aa
   nrg1,  D.rerio
neuregulin 1
    NP_001264013.1
725 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
?Schizophrenia, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

A role for Schwann cell-derived neuregulin-1 in remyelination.
Stassart RM, et al. Nat Neurosci 16, 48-54 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Neuregulin (pfam02158)
  Neuregulin family.
Ig (cl11960)
  Immunoglobulin domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Ig (cl11960)
  Immunoglobulin domain.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 4 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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