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HomoloGene:18982. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LRRK2,  H.sapiens
leucine-rich repeat kinase 2
    NP_940980.3
2527 aa
   LRRK2,  P.troglodytes
leucine-rich repeat kinase 2
    XP_001168494.1
2527 aa
   LRRK2,  M.mulatta
leucine-rich repeat kinase 2
    XP_002798616.1
2430 aa
   LRRK2,  C.lupus
leucine-rich repeat kinase 2
    XP_543734.3
2527 aa
   LRRK2,  B.taurus
leucine-rich repeat kinase 2
    NP_001193015.1
2527 aa
   Lrrk2,  M.musculus
leucine-rich repeat kinase 2
    NP_080006.3
2527 aa
   Lrrk2,  R.norvegicus
leucine-rich repeat kinase 2
    NP_001178718.1
2526 aa
   LRRK2,  G.gallus
leucine-rich repeat kinase 2
    XP_003640388.2
2531 aa
   lrrk2,  X.tropicalis
leucine-rich repeat kinase 2
    XP_002932250.2
2514 aa
   lrrk2,  D.rerio
leucine-rich repeat kinase 2
    NP_001188385.1
2533 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Parkinson disease-8.



Publications
Articles associated with genes and sequences of this homology group.

Characterization of NAADP-mediated calcium signaling in human spermatozoa.
Sánchez-Tusie AA, et al. Biochem Biophys Res Commun 443, 531-6 (2014).
Non-motor and motor features in LRRK2 transgenic mice.
Bichler Z, et al. PLoS One 8, e70249 (2013).
New mutations causing familial parkinsonism.
Rana AQ, et al. Ann Acad Med Singapore 42, 307-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lrrk2 includes H.sapiens LRRK2 and R.norvegicus Lrrk2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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