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HomoloGene:56495. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LDHA,  H.sapiens
lactate dehydrogenase A
    NP_001158886.1
361 aa
   LDHA,  P.troglodytes
lactate dehydrogenase A
    NP_001029268.1
332 aa
   LDHA,  M.mulatta
lactate dehydrogenase A
    XP_001086967.1
332 aa
   LDHA,  C.lupus
lactate dehydrogenase A
    XP_534084.4
361 aa
   LDHA,  B.taurus
lactate dehydrogenase A
    NP_776524.1
332 aa
   Ldha,  M.musculus
lactate dehydrogenase A
    NP_001129541.2
361 aa
   LDHA,  G.gallus
lactate dehydrogenase A
    NP_990615.1
332 aa
   ldha,  X.tropicalis
lactate dehydrogenase A
    NP_989153.1
332 aa
   ldha,  D.rerio
lactate dehydrogenase A4
    NP_571321.1
333 aa
   ImpL3,  D.melanogaster
Ecdysone-inducible gene L3
    NP_476581.1
332 aa
   AgaP_AGAP004880,  A.gambiae
AgaP_AGAP004880
    XP_001688556.1
332 aa
   ldh-1,  C.elegans
ldh-1
    NP_496503.1
333 aa
   AT4G17260,  A.thaliana
AT4G17260
    NP_193459.1
353 aa
   Os02g0105400,  O.sativa
Os02g0105400
    NP_001045619.1
392 aa
   Os06g0104900,  O.sativa
Os06g0104900
    NP_001056552.1
360 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Encodes a transcript associated with membrane-bound polysomes in imaginal discs and expressed only in response to 20-hydroxyecdysone (20 HOE). Expression studied both in vitro and in vivo. A 'late' gene involved in the eversion to the exterior of the elongated regions of discs by means of local changes in cell shape (Osterbur, Fristrom, Natzle, Tojo and Fristrom, 1988).

H.sapiens
Exertional myoglobinuria due to deficiency of LDH-A.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN02602 (PLN02602)
  lactate dehydrogenase.
LDH_MDH_like (cl17195)
  NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ldha includes H.sapiens LDHA and R.norvegicus Ldha.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (30 transcripts, 19 species)
Actinopterygii - bony fishes (19 transcripts, 12 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 8 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (38 transcripts, 29 species)
Liliopsida - monocots (13 transcripts, 8 species)
Coniferopsida - conifers (4 transcripts, 2 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (6 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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