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HomoloGene:2438. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   THBS2,  H.sapiens
thrombospondin 2
    NP_003238.2
1172 aa
   THBS2,  P.troglodytes
thrombospondin 2
    XP_003311640.2
1370 aa
   THBS2,  M.mulatta
thrombospondin 2
    XP_001096616.2
1126 aa
   THBS2,  C.lupus
thrombospondin 2
    NP_001184085.1
1171 aa
   THBS2,  B.taurus
thrombospondin 2
    NP_789861.1
1170 aa
   Thbs2,  M.musculus
thrombospondin 2
    NP_035711.2
1172 aa
   Thbs2,  R.norvegicus
thrombospondin 2
    NP_001162609.1
1172 aa
   THBS2,  G.gallus
thrombospondin 2
    NP_001001755.1
1178 aa
   thbs2,  X.tropicalis
thrombospondin 2
    XP_002931559.2
1181 aa
   LOC100535241,  D.rerio
thrombospondin-2-like
    XP_003199793.2
1175 aa
   thbs2b,  D.rerio
thrombospondin 2b
    XP_694690.6
1181 aa
   thbs2a,  D.rerio
thrombospondin 2a
    XP_005157071.1
1175 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lumbar disc herniation, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Expression of thrombospondin-2 as a marker in proliferative diabetic retinopathy.
Abu El-Asrar AM, et al. Acta Ophthalmol 91, e169-77 (2013).
Disruption of thrombospondin-2 accelerates ischemic fracture healing.
Miedel E, et al. J Orthop Res 31, 935-43 (2013).
Increased thrombospondin-2 in human fibrosclerotic and stenotic aortic valves.
Pohjolainen V, et al. Atherosclerosis 220, 66-71 (2012).
Circulating levels of the anti-angiogenic thrombospondin 2 are elevated in pre-eclampsia.
Stenczer B, et al. Acta Obstet Gynecol Scand 90, 1291-5 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TSP_C (pfam05735)
  Thrombospondin C-terminal region.
TSP_3 (pfam02412)
  Thrombospondin type 3 repeat.
EGF_3 (pfam12947)
  EGF domain.
TSPN (smart00210)
  Thrombospondin N-terminal -like domains.
TSP_1 (pfam00090)
  Thrombospondin type 1 domain.
VWC (pfam00093)
  von Willebrand factor type C domain.
EGF_3 (pfam12947)
  EGF domain.
TSP_1 (cl15278)
  Thrombospondin type 1 domain.
VWC (cl17735)
  von Willebrand factor type C domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Thbs2 includes H.sapiens THBS2 and R.norvegicus Thbs2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 12 species)
Actinopterygii - bony fishes (6 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

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