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HomoloGene:18765. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CRTC2,  H.sapiens
CREB regulated transcription coactivator 2
    NP_859066.1
693 aa
   CRTC2,  P.troglodytes
CREB regulated transcription coactivator 2
    XP_003949646.1
599 aa
   CRTC2,  M.mulatta
CREB regulated transcription coactivator 2
    XP_001112030.1
694 aa
   CRTC2,  C.lupus
CREB regulated transcription coactivator 2
    XP_855142.1
696 aa
   CRTC2,  B.taurus
CREB regulated transcription coactivator 2
    NP_001069718.1
693 aa
   Crtc2,  M.musculus
CREB regulated transcription coactivator 2
    NP_083157.1
692 aa
   Crtc2,  R.norvegicus
CREB regulated transcription coactivator 2
    NP_001029067.1
691 aa
   crtc2,  X.tropicalis
CREB regulated transcription coactivator 2
    XP_004921516.1
579 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

CRTC2 is required for β-cell function and proliferation.
Eberhard CE, et al. Endocrinology 154, 2308-17 (2013).
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity.
Wang Y, et al. Proc Natl Acad Sci U S A 107, 3087-92 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TORC_M (pfam12885)
  Transducer of regulated CREB activity middle domain.
TORC_C (pfam12886)
  Transducer of regulated CREB activity, C terminus.
TORC_N (pfam12884)
  Transducer of regulated CREB activity, N terminus.
TORC_N (pfam12884)
  Transducer of regulated CREB activity, N terminus.
TORC_C (pfam12886)
  Transducer of regulated CREB activity, C terminus.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Crtc2 includes H.sapiens CRTC2 and R.norvegicus Crtc2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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